MAO inhibitors - what is it ?
Miscellaneous / / August 12, 2017
MAO inhibitors - chemical slows the enzymatic reaction of monoamine oxidase.Some psychotropic drugs and substances of natural origin are classified as MAO inhibitors.monoamine oxidase inhibitors are conditionally subdivided into specific groups according to the properties possessed.In particular, there are reversible and irreversible MAO inhibitors, as well as selective and non-selective.
reversible option should be regarded as a complex of inhibitor and monoamine oxidase.During active action and release of the disintegration inhibitor and subsequently output material from the body through the bloodstream.The enzyme is not damaged.
irreversible MAO inhibitors interact with monoaminksidazoy at the level of the chemical bonds.In this case there is loss of metabolization enzyme and final properties.However, the body synthesizes new enzyme.Selective inhibitors act selectively against one of the two types of MAO, while non-selective respectively act independently of MAO type.
These inhibitors are in the process of reducing or suppressing monoksidazy action, enhance urovnyamediatornyh monoamines in the synaptic cleft.At the same time there is a growing monoaminergic transmission of nerve impulses.In connection with this state of things, these substances are mainly used as antidepressants.MAO-B inhibitors are, inter alia, are used in the treatment of Parkinson's disease as well as in the treatment of narcolepsy.It should be noted: some drugs must be carefully taken in combination with inhibitors of monoaminksidazy.Basically we are talking about the preparations, which contain substances that affect the exchange of monoamines.The fact that the combined use of these drugs may be associated with uncontrolled amplification action that becomes life-threatening.
Food incompatible with MAO inhibitors
As well as the combination with certain drugs, danger to life may be eating certain foods.In particular, we are talking about products, as part of which contains different kinds of monoamines.Tyramine, tyrosine, tryptophan and other similar substances contained in foods may lead to such conditions, such as hypertensive crisis or serotonin syndrome.Uninitiated probably quite difficult to understand from this rather complicated opus.To understand should perhaps mention those foods that are not recommended for use in food, as incompatible with MAO inhibitors:
- products cheese production;
- certain alcoholic beverages, including beer,
- meat products processing;
- pickled, smoked, dried food;
- brewer's yeast and yeast extracts;
- pickled cabbage, lentils, beans, soybeans;
- dairy products;
- other foods, including fruit.
Possibility or impossibility of use of certain products is generally regarded as a function of what, in terms of classification, the inhibitors used.