Dioksidin the nose children : drip or not
Medicine / / May 18, 2016
- Dioksidin - that is, its mechanism of action
- release form and application dioksidina
- Side effects and contraindications
- Application dioksidina children with bacterial rhinitis
In the case of bacterialinfection in a child's nose, which is insensitive to most antibiotics, the need arises to its destruction by means of powerful antimicrobial agents.One of these drugs is dioxidine which relates to the pharmacological group of chemically synthesized antibacterials.
Dioksidin - that is, its mechanism of action
To destroy a bacterial infection in the human body uses several pharmacological groups of drugs with different mechanisms of action:
- Antibiotics - natural substances produced by mold fungi to inhibit the growth and reproduction of bacteria.Widely used in medicine as natural antibiotics and their synthetic or semi-synthetic analogues.During evolution, many bacteria develop resistance (resistance) to the antibiotics, which greatly complicates the treatment of bacterial infections.
- Antiseptics - chemical compounds that effectively kill bacteria (bactericidal action) in contact with them.This group of assets is used only externally, as it has toxic effects if swallowed human body.
- chemically synthesized antibacterial agents - this group of drugs is a cross between antiseptics and antibiotics.Representatives of such preparations exert a powerful bactericidal activity thereto in bacteria do not develop resistance.At the same time they provide a sufficiently strong toxicity to the human body, in contact with a large quantity of substance in the blood.This group of antimicrobials include dioxidine.
Dioksidin is a chemical derivative of quinoxaline.Its bactericide action is realized by disrupting bacterial cell wall synthesis which leads to their death.It is active against most bacteria that are resistant to common antibiotics - Klebsiella, Staphylococcus, Streptococcus, Pseudomonas, and E. coli.There are also data on its efficacy in treating anthrax and gangrene.
Product form and application dioksidina
Dioksidin relates to antibacterial agents of the second row, which means that its use is indicated in adult severe infection in humans, caused by bacterial strains that are resistant to antibiotics.This medication comes in 2 dosage forms:
- Injection - is available in 5 ml ampoules, solution concentration of 0.5% and 1%.In this form, it is used for washing festering wounds, body cavities, which occurs purulent infection process (the cavity of the pleura, peritoneum, pericardium).Also, it is administered intravenously to adults, but only on the strict condition that the possibility of other antimicrobials exhausted.
- Ointment - a dosage form used to treat various skin etiotrop infectious diseases.
Side effects and contraindications
group of substances (quinoxaline), which include dioxidine is chemically active compounds.When injected into the cell, it is actively involved in metabolism, blocks the number of enzyme systems and reacts with the genetic material (DNA and RNA), resulting in point mutations.All these properties dioksidina affect its toxicity and lead to the development of a number of side effects:
- pronounced teratogenic effect on the growing fetus - the drug is absolutely contraindicated in pregnant and lactating women;
- development of allergies;
- dyspeptic syndrome - nausea, periodic vomiting, unstable stool, cramping and abdominal pain;
- hyperthermia - the rise in body temperature;
- local spasms of separate groups of muscles in the form of twitches (the manifestation of toxic effects on neuromuscular synapses);
- photosensitizing effect - resulting in burns when exposed to direct sunlight on the skin.
According to recent research dioksidina, proven role in the development of point mutations in the cells of the body, they can also be inherited - mutagenic effect.In this regard, the list of contraindications to the drug significantly extended instruction - adrenal insufficiency, kidney, can not apply to children under 18 years of age, pregnant and lactating women, people with high sensitivity.
Application dioksidina children with bacterial rhinitis
In the recent past, dioxidine nose actively used for children in the form of drops.The child in the development of bacterial rhinitis (persistent, long runny nose, nasal congestion, accompanied by a greenish-yellow discharge) used on the basis of drops dioksidina, dozirovka- 0.5% solution of 2 times a day.1% solution must be diluted before use with water or saline solution boiled in 2-fold (0.5% solution was obtained).
also based dioksidina produced complex drops, which in its composition in addition included hydrocortisone (anti-allergic and anti-inflammatory effect) and epinephrine (a vasoconstrictor, reduces swelling of the nasal mucosa and improves breathing).In general, it has a marked effect on the primary destruction of infection, which clearly liked the doctor and parents.
Today, thanks to what has been proved toxic and mutagenic effect dioksidina, official medicine does not recommend the use of his child with bacterial rinite.Tem Still, some doctors now prescribe drops by dioksidina in chronic rhinitis, which does not respond to antibiotics.
Before figure out how to drip into the baby's nose dioksidina solution, you must carefully weigh the pros and cons of using this drug.Indeed, to date, there are many effective and safe local antiseptics, which was not in the days of active use dioksidina.