If the average platelet volume increased or decreased - what does it mean ?
Analyses And Studies / / May 07, 2016
- Platelets: blood counts
- blood test: determination of MPV
- abnormalities Symptoms, treatment
Platelets: blood counts
platelets, beingthe smallest elements of blood (cell size is 2-4 microns), are responsible for the full operation of the circulatory system.From these cells depends on blood viscosity and the ability to restore the integrity of the blood vessel by thrombus formation at the site of damage.
physiological indicators of absolute number of platelet cells varies within 180-400h109 / l.During the day, the number of blood cells may vary by 10%.A significant decrease of this indicator in 80% of cases describes various bleeding from nose to more serious in the internal organs.The rate among women
average size characterizes the maturity of blood cells.Normal is considered to be an indicator of the amount of 7-10 fl (femolitr).Platelet lives of 8-12 days.Immature young cells have an increased volume, while the "old", on the contrary, decrease in size.
blood test: determination of MPV
5 ml of blood (the children take 1-2 mL) was taken from a vein.Cytometric analysis is performed using fluorescence analysis.In this hematologic analyzer generates a histogram - a graph showing the number of different sized platelets.Young, mature and ends his life cells carry different functional load of different intensity of biologically active substances.The predominance of immature platelet content shifts the histogram to the left.The shift to the right is characterized mainly by the content of the old cells.Such changes may occur during normal indicator of the absolute number of platelets, which means violation of any cell of the educational process in the bone marrow, or their maturation.
causes of variances
large number of young platelet cells improves blood clotting and is fraught with the formation of blood clots.The average volume of platelets increased in the following pathological conditions:
- post-hemorrhagic anemia (compensating for the loss of blood, the bone marrow produces hard young cells);
- thrombocytopenic purpura;
- thalassemia (a hereditary disease);
- splenectomy (removal of the spleen);
- Mey anomaly - Hegglina (rare);
- trombotsitodistrofiya Bernard - Soulier;
average volume of platelets is below normal (the predominance of old cells) characterizes the decrease in blood coagulation ability, the ability to extensive bleeding and wounds nezazhivlenie.Thrombocytopenia (decrease in the total number of platelets) and an understated figure of absolute volume of these cells is a sign of the following pathologies:
- splenomegaly (enlarged spleen in volume);
- aplastic, megaloblastic anemia;
- cirrhosis of the liver;
- oncopathology (leukemia, sarcoma, lymphoma, carcinoma, Hodgkin's disease) and concomitant radiotherapy and cytostatic treatment;
- syndrome Wiskott - Aldrich syndrome (hereditary pathology);
- myelodysplastic syndrome.
Important: Lowered the amount of platelets can be detected during pregnancy.Thrombocytopenia is usually small, but the risk of miscarriage and premature birth is increased threefold.
Thrombocytopenia and the concomitant decline in the absolute volume of the cells may have pharmacological etiology.Reception following drugs inhibits platelet synthesis:
- atsetilsalditsilovaya acid (aspirin);
- Biseptol and sulfonamides;
increased average volume of platelets in the blood greatly increases the chance of thrombosis, resulting in a serious condition, up to a heart attack, stroke or thromboembolism.This is particularly dangerous for patients with hypertension and diabetes.At a high level, the volume of prescribed drugs that can reduce blood viscosity.
low indicator is fraught with breakthrough bleeding, which stops very often causes difficulties.Treatment of thrombocytopenia is the use of medications that increase blood viscosity: IV etamzilat sodium, chloride, calcium, etc., inside the iron preparations and vitamin complexes topically hemostatic sponge..In severe thrombocytopenia and abundant incessant bleeding prescribe transfusions of platelets and plasma donation.However, if this measure will lead to increased bleeding in the blood of antiplatelet antibodies.
small deviation level of the average amount of platelet cells, possibly caused by SARS usual, does not require treatment.However, caution should be exercised in the selection of antibacterial and antiviral medication, so as not to cause further decline.Control of the total number of platelets and their absolute volume is required as proof of the effectiveness of the prescribed treatment of the underlying disease and prophylactic (prevention of thromboembolism, major bleeding).Analysis to identify the level of the average cell volume must be repeated periodically to patients with diabetes, hypertension, thyroid disease.