Tumor markers of ovarian CA 125 : decoding and rate
Analyses And Studies / / May 05, 2016
- What is CA 125?
- When CA 125 above the norm?
- How to donate blood for tumor markers?
- Decoding results
What is CA 125?
This high molecular weight glycoprotein that is detected in the endometrial cells of the pleura and pericardium, peritoneum and the testes in men.In addition, this compound is present in the epithelium of the pancreas, gall bladder, kidney and bronchi, stomach and intestines.It is believed that the SA 125 - tumor marker, which indicates a high concentration on the serous ovarian cancer, but it is important to remember that the level of its gr
When CA 125 above the norm?
CA 125 level increases in cancer of the ovaries (in 80% of cases), tumors of the uterus and its appendages, breast, lung, pancreas, and the digestive organs (stomach, liver, intestines).
In addition, the concentration of CA 125 significantly increased in certain somatic diseases, among which are the following:
- gynecological infections;
- inflammation of the fallopian tubes;
- inflammation of the pleura, or pericardium;
- benign ovarian cyst;
- chronic inflammatory processes in the liver or the destruction of its cells (cirrhosis);
- chronic inflammation of the pancreas (pancreatitis);
- autoimmune diseases;
- CA 125 also increases in endometriosis.
Keep in mind that the increase in CA-125 levels observed during menstruation or during pregnancy (in the first trimester of gestation).The highest concentration of this compound is registered in the amniotic fluid, blood serum of a woman, as well as in breast milk.This is considered normal and does not require any treatment or additional diagnostic tests.
How to donate blood for tumor markers?
To determine the level of tumor markers is carried out strictly fence from a vein on an empty stomach.After the last meal should be at least 8 hours.In addition, for 30 minutes before putting the analysis of non-smoking.Women also important to remember that such laboratory analyzes shall be handed over in the first phase of the menstrual cycle (the second or third day after the end of menstrual bleeding).
important to know that in the laboratory blood parameters can be affected by other diagnostic procedures, such as x-ray, ultrasound, gynecological taking smears, biopsy, Colon -, gastro or bronchoscopy.If carried out anti-tumor treatment, re-determination of tumor markers should be performed every 3 months, so the date of delivery of the analysis needs to be coordinated with the attending physician.
results Interpretation of the data makes it exceptionally doctor as often receive false-positive results, which should be compared with current clinical manifestations and comorbidities.
Norma tumor marker CA 125 in women is less than 35 U / ml for men - 10 U / ml.In some cases, the figure remains in the normal range even in the presence of cancer pathology.This is due to the fact that the tumor does not synthesize CA 125, so it may not be a diagnostic marker.In addition, the test results may be normal if the tumor process in the early stages of development.
Because of this pattern of blood tests for tumor markers CA 125 is not used for the purpose of screening.As a rule, he was appointed to monitor ovarian serous tumors and early detection of recurrence.Thus, reducing the concentration of CA 125 during treatment allows you to make favorable forecasts for the further course of the disease.If its level is increased by 2 times and not reduced, it indicates that the tumor does not respond to treatment.
should be noted that in cases where the CA level 125 is normal, but the woman refers to the risk (for example, it has recorded a violation of ovarian functioning, chronic adnexitis, bleeding in postmenopausal women) can be assigned to the analysis on a more specific and sensitive tumor marker - NOT4. It allows you suspect epithelial ovarian cancer, and at diagnosis - timely detection of recurrence of the disease.It is important that this tumor marker in contrast to the CA 125 is not increased gynecological diseases, endometriosis or cystic ovaries.In addition, its high secretion level observed for the cancer at all stages of the process, which has a greater diagnostic value.
important to remember that laboratory tests can not be considered the sole criterion for a correct diagnosis.Correctly evaluate an increase or decrease in the level of an indicator can only qualified physician in view of other surveys and data available to the patient's clinical symptoms.