Antibodies to thyroid peroxidase : the rate and reasons for the increase
Analyses And Studies / / August 12, 2017
- What norm AT TPO?
- reasons for raising antibodies to TPO
- high level AT TPO in pregnant
Antibodies to the microsomal peroxidase (this is the same thing as thyroid peroxidase or TPO) are complex protein compounds (immunoglobulins) which are produced in the human body becausethat the immune system begins to perceive the enzyme thyroid peroxidase contained in the cells of the thyroid gland, as something alien.
The interaction of antibodies to thyroid peroxidase (TPO antibodies) with the enzyme, the last activity decreases, respectively, the processes in which it participates, stop its development.And it participates in reactions of thyroid hormone synthesis, and the greater the amount of the enzyme is inactivated, the smaller the amount of thyroid horm
Therefore, almost all patients with problems on the part of the body (especially when all indicates its hypofunction) doctors prescribe a blood test for antibodies TPO.This study makes it possible to understand the endocrinologist, has in the body autoimmune process directed against the thyroid gland, or not.
What norm AT TPO?
normal value of this indicator depends on how the research was conducted, what the test system used and the concentration of antibodies measured in any units.Therefore, assessing the results of the analysis should always be based on the reference values for the laboratory.It can be a table, which contains the rate for women and men in different age groups, although AT TPO reference values are usually the same in all groups surveyed.
is also worth noting that 10% of the investigated people (mostly women) found the upper limit of normal or slight increase in the number of antibodies to thyroid peroxidase in the absence of any pathology by the thyroid gland.This explains the need to assess the rate of TPO antibodies only in conjunction with other laboratory data and the results of clinical and instrumental body of research.
reasons for raising antibodies to TPO
Since immunoglobulins thyroid peroxidase - are autoantibodies, intensive synthesis of the body is observed in autoimmune processes in the thyroid gland, due to which these diseases develop:
• thyroiditis (organ inflammation), are chronic, subacute.
• Diffuse or nodal increase organ.
• Hypothyroidism - reducing endocrine function of the thyroid gland.
In addition, elevated TPO antibodies and a number of other violations of the thyroid gland is sometimes diagnosed in new mothers who had not suffered any abnormalities of the body.In such cases there is also an autoimmune process that is likely to develop due to serious aberrations in the immune system and the functioning of the thyroid gland during pregnancy.These problems may disappear on their own (approximately 8 months), but most doctors have to conduct a serious treatment to dysfunction of this important endocrine organ has not taken a permanent nature.
In addition, the rate of AT TPO above normal can be in other autoimmune diseases, non-endocrine organs, such as lupus erythematosus, scleroderma and so on. This again confirms that regard a high level of antibodies to microsomal peroxidase as an indicator of pathological changesin the thyroid gland can be in the presence of three criteria: clinical manifestations of organ dysfunction, specific changes in the US and data indicating hypothyroidism (insufficient production of thyroid hormones), when studying the hormonal profile of the patient.
high level of TPO antibodies in pregnant
Determination of thyroid peroxidase antibody levels in pregnant women is shown with an increase in the size of the thyroid gland and increase the level of thyroid stimulating hormone (TSH) - pituitary hormone that regulates the production of thyroid hormones.The concentration of thyroid hormones themselves may be normal.
This survey algorithm is explained by the fact that a woman can be hidden hypothyroidism, which can manifest at any time, because during pregnancy the thyroid gland feels severe stress.That is a high level of antibodies to TPO with a high level of TSH indicates a problem with the thyroid gland in the future mother and a big risk for her child, because hormone deficiency affects its development.
In such situations, women showed hormone replacement therapy, which can significantly reduce the chance of fetal death, birth of a baby with abnormalities and the appearance of the child's various health problems in the future life.