Tek - cell tumors of the ovary Tecom
Endocrinology / / August 12, 2017
Tumors of the elements of the female gonads (feminizing ovarian tumors)
Tecom as an independent disease marked Leffler and Prizelem in 1932 (Loffler and Priesel).
It is recognized mesodermal tumor histogenesis.Consider the source of origin of Tecom stromatogennye fusiform ovary cells.Cellular elements of the follicle structure is repeated at different stages of its development.
tumor in shape often resembles the ovary.The surface of the tumor is smooth, sometimes krupnobugristaya, thick consistency.At TECOM section have a characteristic yellow color.Grossly, along with denser portions tissue cavity can be serous or bloody contents.Microscopic Tecoma built of strands and clusters of spindle-shaped cells with scant cytoplasm and elongated nuclei good coloring.Stroma number is small, and it consists of individual fibers argyrophilic enveloping each cell.These sites Tecom functionally inactive.Functionally active part of Tecom are areas of spindle cells, transformed into epithelioid round
According to the literature, the disease incidence (relative to ovarian tumors) is about 40%.Most diseases falls on the age over 55-60 years.The average age of Tecom detection - 47 years.At a young age (before 20 years) Tecom are very rare.In women of reproductive age the first signs of the disease are disorders such as monthly Meno-metrorrhagia and secondary infertility.In the elderly group of patients with a characteristic feature of the disease is the occurrence of uterine bleeding after menopause.Gynecological examination of these patients reveals that the sexual apparatus has no signs of age-related physiological atrophy.
Typically Tecom is a source of estrogen production.Prolonged giperestrogen and I leads to the proliferation of uterine mucosa, vagina, as well as an increased number of tumors - uterine fibroids (up to 50% of cases) and cancer of the uterus.However, some waviness in the clinical manifestations, in particular the appearance of bleeding, apparently due to periodic increase in estrogen production.At this point the frequency of urinary estrogen histochemical studies).
tumor usually affects one ovary.Tumor sizes vary from a few centimeters in diameter to a head size unit with adult.amenorrhea, increased libido and hypertrichosis, coarsening of voice and clitoral enlargement -
In more rare cases, the presence of Tecom virilization symptoms can occur.Finally, there may be a complete absence of hormonal activity of the tumor.
- hormone producing tumors of the ovaries
- ovarian hormones the ovaries.Androgens
- Biological effects of catecholamines
- diagnosis and treatment of pheochromocytomas
- Diseases of the adrenal medulla
- Treatment of chronic adrenal insufficiency
- Diseases of the thymus (thymus) gland
- relationship thymus gland with endocrine glands
- thymus gland and its physiology
- Acuteadrenocortical insufficiency
symptoms development is slow, especially in those in menopausal and postmenopausal women: usually first menopause, and then, a few yearslater, the symptoms of the disease develop.
Tecom are tumors, giving a small percentage of malignant transformation.The literature describes 14 cases of malignancy Tecom 300 described disease, which is 4%.Malignant Tecom exhibit fewer signs of hormonal activity.