STATUS THYMICOLYMPHATICUS lymphoidotoxemia
Endocrinology / / May 23, 2016
This condition was first described in 1889 Paltauf Status thymico-lympha-ticus is an innate feature of the constitutional body.This condition is characterized by hyperplasia of the thymus and all the lymphoid tissue.From the blood in most cases the relative and absolute lymphocytosis, eosinophilia.In addition, in patients with status thymico-lymphaticus observed pale skin, a tendency to obesity, poor muscle development, muscle weakness, hypoplasia of the cardiovascular system (narrow aorta, drip heart, a tendency to hypotension).External and internal genitals, gonads also underdeveloped.Secondary sexual characteristics are often poorly expressed.Changes skeleton expressed in prevalence over the length of the limbs of the body length, frequently observed lordosis lumbar spine.X-ray revealed later epiphyseal nesmykanie zones.A typical manifestation of status thymico-lymphaticus considered low blood sugar.Persons with this condition are very susceptible to various infectious and skin diseases.
With status thymico-lymphaticus associated cases of sudden death (mors thymica) when exposed to different, sometimes seemingly innocent factors: the feeling of the neck, a cold bath, anesthesia, nervous excitement, physical exertion, etc. In the section other than hyperplasia..thymus, no changes, which could be attributed the sudden death, can not be detected.mors thymica mechanism remains unclear.Authors who deny the secretory function of the thymus gland, the cases of sudden death in status thymico-lymphaticus explain the mechanical compression of the trachea dramatically increased the thymus gland.The researchers, coming from the recognition of the thymus gland secretory function of the prostate hyperplasia, and considering both factors contributing to enhancing its secretory activity, try to connect with mors thymica excessively toxic effects produced by secretion of the thymus gland in the vital organs, especially the heart.
Most researchers, especially foreign direct cause of sudden death in status thymico-lymphaticus considered insufficient function of the adrenal cortex hormones that are known to be necessary for the emergence of a defense mechanism in response to the "stress".This view is confirmed by the fact itself, that section of the cases of sudden death from unexplained causes found in most cases of adrenal hypoplasia.
Isolated increase in the thymus, is not accompanied by hyperplasia of the lymphoid organs, has been called status thymicus.This condition occurs mostly in infancy and revealed the so-called asthma thymicum.According to the observations with symptoms of difficulty breathing in newborns increase thymus radiographically detected in 41.2%.Symptoms "asthma", apparently due not only to increased mechanical pressure on the thymus mediastinal organs, but some toxic factors.Clinically, asthma thymicum manifested by periodic bouts of difficulty, mainly inspiratory breath.During an attack of shortness of breath cough appears swollen neck veins, develops cyanosis face.Often there is a change of voice up to aphonia, which is associated with damage to the recurrent laryngeal nerve.Asthma attacks can result in lethal.In some cases in children with a significant increase in thymus any asthma symptom is not observed.
- Physiology of the adrenal cortex
- Cushing syndrome - Cushing
- diagnosis and course of the syndrome Cushing's
- Treatment syndrome Cushing's
- androgen-producing tumors of the adrenal cortex
- Biological effects of catecholamines
- diagnosis and treatment of pheochromocytomas
- Diseases of the adrenal medulla
- treatment of chronic adrenal insufficiency
- Diseases of the thymus (thymus) gland
- relationship thymus gland with endocrine glands
- thymus gland and its physiology
- Acute adrenocortical insufficiency
Staging of disease diagnosis is associated with great difficulties, because many pathological processes in the nasopharynx, peribronchial lymph nodes, trachea and bronchi may be accompanied by similar symptoms to asthma thymicum.On percussion data can not be relied upon for sound shortening can give enlarged lymph nodes, large vessels of the heart base.The assumption of asthma thymicum confirmed, if appropriate clinical X-ray revealed the mid situated directly behind the breastbone enlarged shadow of the thymus gland.
Increasing the thymus gland in children without clinical manifestations of the disease, of course, does not require any therapeutic intervention.When expressed asthma attacks carried radiotherapy.However, it should be borne in mind carcinogenic effects of radiotherapy on the thyroid gland and the possibility of developing thyroid cancer later in life of people undergoing radiation therapy in childhood.
The thymus gland is highly sensitive to X-rays.Under the influence of X-ray iron rapidly reduced in size, thus disappearing all clinical manifestations of the disease.More efficient radiotherapy makes redundant the recommendations of some surgeons perform with asthma thymicum resection of the thymus gland.
With regard to therapeutic interventions for status thymicolymphaticus, they are reduced mainly to measures careful hardening and recommendations to avoid possible infections, anesthesia, intoxication.Some endocrinologists recommend the use of calcium supplements in combination with phosphorous or arsenic.