Morgagni syndrome - Stewart - Morel (MORGAGNI - MOREL - STEWART)
Endocrinology / / May 23, 2016
syndrome Morgagni - Stewart - Morel - a disease characterized by the presence of hyperostosis inner plate of the frontal bone, obesity and a number of other metabolic and endocrine disorders.This syndrome occurs almost exclusively in women, usually over the age of 40 years, however, it occurs at a younger age - up to 30 years.
The feasibility isolation syndrome Morgagni - Morel - Stewart in a separate pathological form associated with diseases of the endocrine glands, can not be considered a foregone conclusion, as endocrine disorders described in this syndrome - hypertrichosis, disorders of carbohydrate metabolism - occur with other forms ofgross obesity.As for the characteristic signs of the disease - hyperostosis inner plate of the frontal bone, that there is insufficient evidence to link it with the pathology of the endocrine system.
Etiology Morgagni syndrome - Morel - Stewart unknown.Bertolotti, Nicotra attach importance in the origin of chronic diseases pansinusitu.Silinkova an
Morel suggests a role in the pathogenesis of the disease increased production of estrogen.Julesz and Hollo bind Morgagni syndrome - Morel - Stewart with an increase in the anterior pituitary function, manifested by increased secretion of hormones produced as a basophilic and eosinophilic cells.None of these assumptions is not confirmed sufficiently convincing hormonal studies.
addition to thickening of the inner plate of the frontal bone, sometimes - in hyperostosis occipital and fronto-occipital areas of the syndrome of Morgagni - Morel - Stewart describes the various, mostly microscopic changes in endocrine glands.The pituitary Morel observed an increase in the number of eosinophilic cells, Barthelheimer - basophilic adenoma, Fallo-vich - how to increase the number of basophilic and eosinophilic cells.Julesz and Hollo is a description of patients who were in the pituitary adenomatous growths consisting of basophil, eosinophil and chromophobe cells.In addition microadenomas pituitary, in this patient were found adenoma of the thyroid gland, parathyroid, and adrenal cortex.
Patients complain of severe chronic headaches, which are not directly dependent on the degree of hyperostosis.A typical symptom is severe obesity with preferential deposition of fat in the abdominal area.The skin of normal color, no stretch marks.Often there are weeping eczema, pyoderma.In most patients there is a more or less pronounced hypertrichosis.There pasty skin, swelling of the lower extremities, akrotsianoz.The muscular system is underdeveloped.On the part of the cardiovascular system and respiratory system to detect changes characteristic of patients with severe general obesity - expansion of borders of the heart, voiceless heart tones signs of heart failure.Blood pressure is often elevated.There is a tendency to collapse.The lungs are often congestion, there is a tendency to catarrh of the upper respiratory tract and pneumonia.
Changes functions of the endocrine glands have no special features.Basal metabolic rate can be either normal or low or high.Often there is a decrease of tolerance to carbohydrates - abnormally high sugar and tightened curves or is diabetic.In addition, some patients sugar curves flattened, low.The menstrual cycle can be broken.However, against this background, pregnancy may occur that usually worsen the condition of patients.
describes the case of a combination of Morgagni syndrome - Morel - Stewart with diabetes insipidus.
Often there are neuro-psychiatric disorders - emotional lability, irritability, tendency to depression, insomnia.
X-ray examination revealed hyperostosis inner plate of the frontal bone, sometimes - a diffuse thickening of the skull bones.In some patients there is a slight increase in the size of the Turkish saddle.
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flow forecast, disabled
It all depends on the degree of obesity.Expressed obesity adversely affect life expectancy.The crux of the heart as a result of fat accumulation in the pericardium and myocardium, high standing of the diaphragm, peripheral circulatory disorders, coupled with obesity is often associated with atherosclerosis and hypertension create conditions for the development of heart failure, which is a cause of disability of patients.
If you have diabetes join metabolic disturbances characteristic of the disease, which lead to a further reduction of working capacity and reduce outlook on life expectancy.
Treatment Treatment is reduced to dietary measures, essentially the same as that in the dietary treatment of patients with diabetes combined with obesity.It is recommended a diet rich in complete proteins, mineral salts and vitamins with a low-calorie due to the decrease in the diet of fat and carbohydrates, proposed by VG Baranov.
additional importance therapeutic exercise, massage to eliminate muscle weakness, improving peripheral circulation.If there is the treatment of heart failure cardiotonics, diuretics and the like. N., As in other heart failure origin.