Pathological anatomy at the anterior pituitary insufficiency
Endocrinology / / May 21, 2016
Morphological changes in the pituitary gland and the hypothalamus are determined by the pathological processes that led to the development of the disease.In the most common form of pituitary pathology dientsefalo-down function of the anterior pituitary - postpartum hypopituitarism - early after onset of the disease are detected vascular changes - thrombosis of blood vessels that supply blood to anterior pituitary, and its necrosis.In rare cases, there are necrosis and neurohypophysis.Later pituitary necrotic areas are replaced by fibrous tissue and morphologically determined by the pituitary gland is very small size, composed of fibrous tissue, which are found among the small group of glandular cells.
to complete or almost complete disappearance of the glandular anterior pituitary tissue may cause compression of its benign (often chromophobe adenoma) or malignant tumors, cysts, infectious granulomas.
Less describes patients with symptomatic failure of the anterior pituitary, in which changes in the pi
thyroid gland, adrenal cortex and gonads atrophic.thyroid weight in some patients who died was only 1 / 3-1 / 4 of the normal, sometimes found lymphoid infiltration and fibrosis gland tissue.The atrophied testes by microscopic examination revealed hyalinosis and thickening of the basal membrane, the absence of spermatogenesis, a significant reduction in the number of Leydig cells.The ovaries are detected only a few primordial follicles;developing follicles and corpora lutea are usually absent.In some cases, there is atrophy of the parathyroid glands.
expressed atrophic changes occur in the internal and external sex organs.
Noteworthy atrophy of internal organs - heart, liver, and other, even for those who died, who cachexia absent or weakly expressed.Atrophic changes occur in the skin and its appendages, muscle and other tissues.Usually it is weight loss, but a pronounced depletion - Cachexia - is rare.
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- Treatment failure of the anterior pituitary
spread of the disease
deficiency of the anterior pituitary in connection with the pathological process in the pituitary gland or dientsefalo-gipofazarnoythe field more often in women.On the 10 000 population has a severe case of 2 and 7 postpartum hypopituitarism lungs.