Encyclopedia Symptoms / / May 17, 2016
Alternative names: acute hemolysis
Hemolytic crisis (an acute attack, which occurs as a result of pronounced erythrocyte hemolysis is observed in blood diseases, congenital and acquired hemolytic anemia, systemic transfusion of incompatible blood, under the influence of various haemolytic.poisons, and after taking certain medications - quinidine, sulfonamides, s-dopirkka, nitrofurans group rezohina etc.
development crisis begins with chills, nausea, vomiting, weakness, cramping pain in the lower back and abdomen, increasing shortness of breath, fever.body, tachycardia, etc. In severe Stroke usually can dramatically decrease blood pressure, collapse and anuria develop enlargement of the spleen is observed frequently, and sometimes liver
for hemolytic crisis is characterized by:.. rapidly developing anemia, leukocytosis, reticulocytosis, increasingof free bilirubin, a positive Coombs test with autoimmune hemolytic anemia, urobilin in the urine, and free hemoglobin during intravascular hemolysi
pathological hemolysis occurs under the influence of cold, hemolytic poisons or medicines and some other factors in sensitized people.Hemolysis is characteristic of hemolytic anemia.According to the localization process emit types of hemolysis - the intracellular and intravascular).Destruction is much faster than the body can produce new blood cells.
hemolytic crisis causes acute (and often severe) anemia (clinical and hematological syndrome, a common phenomenon for which -. Decrease in hemoglobin concentration in the blood, often with a decrease at the same time, the number or the total volume of red blood cells This concept does not define a specific without going into detaildisease, ie, anemia should be considered as one of the symptoms of different pathologies), because with anemia the body can not produce enough red blood cells to replace those that were destroyed.Then a part of erythrocytes, which carry oxygen (hemoglobin) released into the bloodstream that can cause damage to the kidneys.
Common Causes hemolytic crisis
There are many causes of hemolysis, including:
- the absence of certain enzymes within the red blood cells;
- auto-immune diseases;
- some infections;
- defective hemoglobin molecules inside red blood cells;
- defects in the proteins that make up the internal structure of the erythrocytes;
- side effects of medication;
- a reaction to a blood transfusion.
Diagnosis and treatment of hemolytic crisis
patient should see a doctor if they have any of the following symptoms:
- decrease in amount of urine;
- fatigue, pale skin, or other symptoms of anemia, especially if these symptoms are worse;
- urine looks red, red-brown or brown (the color of black tea).
patient may need emergency care.This may include: a hospital stay, oxygen, blood transfusions and other treatments.
When the patient's condition is stable, the doctor will perform a diagnostic examination and ask questions about the patient - for example, such:
- when the patient first noticed the symptoms of hemolytic crisis;
- what kind of symptoms the patient noticed;
- whether the patient's history of hemolytic anemia, G6PD deficiency, or kidney disorders;
- do you have someone in the family of the patient's history of hemolytic anemia or abnormal hemoglobin.
diagnostic evaluation can sometimes show swelling of the spleen (splenomegaly).
tests to the patient may include:
- blood chemistry;
- complete blood count;
- Coombs test (. Or Coombs' test - a test to determine antiglobulin incomplete erythrocytic antibodies This test is used to detect antibodies to the Rh factor in pregnant women and to determine the hemolytic anemia in newborns with Rh incompatibility, entailing the destruction of red blood cells);
- CT scan of the kidneys or the whole of the abdominal cavity;
- ultrasound of the kidneys or the whole of the abdominal cavity;
- analysis of serum free hemoglobin and other