Endocrinology / / May 17, 2016
Where there is evidence of eosinophilic pituitary adenoma patients with pituitary gigantism radiation therapy or surgical treatment as patients with acromegaly.
In the absence of direct evidence for the presence of pituitary tumors issue of suspending the excessive growth usually occurs only in girls.To stop the growth of their proposed treatment with high doses of estrogens on the calculated acceleration epiphyseal cartilage ossification, and possibly lowering the production of growth hormone by the anterior pituitary.Estrogens antagonize the action with respect to growth hormone.
encouraged to nominate estradiol benzoate intramuscularly from 1 to 6 mg a day or stilbestrol inward from 2 to 10 mg daily.When uterine bleeding estrogen dose is doubled.With the help of this treatment in women 14 years and older could make a stop growth during the year.Since the beginning of the treatment of the girls grow no more than 2.5 cm. When using estrogen younger girls to stop the growth required over the long term
There are other patterns of use of large doses of estrogen to stop the growth.It recommends the introduction of estrogen in a total dose of 20-30mg per twenty-day course;followed by three days of progesterone is administered to 10 mg per day, and the treatment is interrupted for 10 days.
- pituitary dwarfism.The clinical picture
- chromophobe pituitary adenoma
- tumors of the anterior pituitary
- clinical picture of acromegaly
- Diagnosis and differential diagnosis of acromegaly
- treatment of acromegaly
- Diagnosis and differential diagnosis of gigantism
It is necessary to warn against the widespread use of large doses of estrogen to stop the growth in young girls.As yet there are no sufficiently long observation that would safely assume that large doses of estrogen at a young age will not have a damaging effect on the gonadotropic pituitary function, hormonal and reproductive function of the ovaries.In particular, it should be considered in those tall girls who have no direct signs of pituitary gigantism and can not be completely ruled out constitutionally tall.
Patients with pituitary gigantism, whose growth has stopped as a result of radiation therapy, but there are signs of hypogonadism, can be used in substitution treatment sex hormones, as with other forms of hypogonadism.
If you have adrenal insufficiency, disorders of carbohydrate metabolism treatment of patients with pituitary gigantism should be carried out as well as patients with acromegaly who have relevant infringement.