Menopause ( Menopause ) in men
Endocrinology / / May 16, 2016
to male menopause include those related neural and hormonal processes, which lead to the termination of the reproductive function.But while in women during certain periods of aging anovulation reproductive function and is a mandatory process, reproductive function in the aging period is terminated only male part, and in part can be maintained even in the aging period.Consequently, the effects of menopause as one of the aging process in men is not required.Termination of the reproductive function in old age is probably already a process of another origin, coordinated with the age-related changes in various tissues and organs.
Morphological and functional changes of the testes in men during aging
Research testicular tissue obtained by biopsy, showed that the majority of men in the age range 45-60 years histological findings did not differ from the corresponding data younger age group.Only a small proportion of individuals in this age were obtained histologic changes corresponding to changes in older
With aging, thickening of the basement membrane and tunica propria tubules and substitution seed epithelial connective tissue.These changes on the part of individuals are relatively early, but after the age of 70 are observed constantly.
Even in old age, along with altered tubules, there are a perfectly normal and a low degree of atrophy.
A number of authors have shown preservation of spermatogenesis in the elderly.Thus, aged 70-80 years spermatogenesis was observed in 59.5%, and 80-90 years of age - 48%.Half of the testes or vas deferens in men older than 70 years had a normal sperm.
seminal vesicle weight decreases with age a little, but the fructose content of the seminal fluid decreases sharply after the third decade.Since the fructose content of the seminal fluid is dependent on androgen production, the weight of the seminal vesicles is not supported by androgens (production of which, to reduce the fructose falls sharply), and some other substances are not androgenic nature.
As can be seen from the above data, with the increase of age observed morphological changes in the testes in the seminiferous tubules, Leydig cells and other elements, however, according to the research, these changes are under the age of 60 years are rare and grow only more senile age periods.According to most authors, spermatogenesis many men preserved up to a ripe old age.
With these data is consistent preservation of reproductive function in some men, not only in the aging period, but also in the old age period.
At the same time there is evidence of progressive age-related decrease in testosterone production.testosterone excretion reaches a peak between 25 and 35 years and to 6-7 decades decreases, reaching a level of puberty.A number of authors have shown age-related decrease in urinary excretion 17-keto steroids, with particularly steep fall occurred in relation to fractions and androsterone etioholanolona.However, these data are less conclusive than the direct determination of testosterone in the urine, due to the fact that both 17-keto steroids in general, and androsterone etioholanolon are also products of metabolism of steroids produced by the adrenal glands.
- primary testicular failure function
- male gonads.Embryology, anatomy and physiology
- diagnosis and treatment of climacteric neurosis
- menstrual cycle
- The use of estrogen for the treatment of climacteric neurosis
- The use of androgens in the treatment of climacteric neurosis
- Early puberty
- Violation of the menstrual cycle rhythm disorder month.Polimenoreya
- principles of hormone therapy violations
- menstrual Principles of hormonal treatment of dysfunctional uterine bleeding
- Prevention of recurrence of dysfunctional uterine bleeding
- Tumor cells Leydigovyh hilyusa ovaries.
Change gonadotropin production with age in men
Only part of men over 50 and 70 years of age there is an increased release of gonadotropinsurine.The study noted the growth of the average level of gonadotropin release in men older than 60 years.Increased allocation of gonadotropins in the elderly mentioned with varying frequency.Increasing release of gonadotropins in men aged 60-69 years was observed only in 2 of 24, and median age urinary gonadotropins rise significantly less in men than in women, and 70 years after their isolation fall replaced.
Age-related changes are observed in the testes, but become more pronounced in individuals after the age of 70, but spermatogenesis is maintained in the majority of women in the aging period, and even old age.Termination and cessation of spermatogenesis fertility occurs only in some women in the aging period.If you put in the foundation of the concept of menopause related neural and hormonal processes, which lead to the termination of the reproductive function, it is necessary to take the position that the Menopause in men in the aging period is not required process.In some persons the termination of the reproductive function occurs in old age period, but this process may be qualitatively different from the process that leads to the cessation of this function in the aging period.