Diagnosis and differential diagnosis of gigantism
Endocrinology / / May 10, 2016
itself diagnostics excessively rapid growth in children or adults of gigantic stature, of course, is not difficult.
Difficulty can arise when deciding whether an abnormally high growth with a pathological process or it is associated is a manifestation of "constitutional" or "primordial" gigantism in a healthy person.
People with constitutional gigantism often born to tall parents have a lot of height and weight at birth, later outperform their peers in growth.A particularly rapid growth noted in boys puberty.Puberty they occur in a timely manner or somewhat premature.In adults, unlike patolologicheskih pituitary giants from healthy constitutional giants is less difficult and is based on availability at the first clinical, radiological and metabolic signs of progressive akromegalizatsii.
Children may need to be in the differential diagnosis between pituitary gigantism and arachnodactyly (Marfan syndrome).Here's constitutional disease, no signs of endocrine disorders.Growth patients usually well above
High growth in patients with primary hypogonadism is usually easily distinguished from pituitary gigantism.In primary hypogonadism genitals dramatically underdeveloped, no secondary sexual characteristics, the skeleton has characteristics eunuchoid proportions, thin bones, muscles are poorly developed.
Sotos syndrome and others have described, which they called "cerebral gigantism" and manifested rapid growth of children, accelerated skeletal maturation and mental retardation.In 3 of 5 patients was identified hydrocephalus.The authors attribute the disease to damage the hypothalamus and perhaps other parts of the brain.The presence of mental retardation and accelerated maturation of the skeleton allows to distinguish the syndrome from a pituitary gigantism.
- pituitary dwarfism.The clinical picture
- chromophobe pituitary adenoma
- tumors of the anterior pituitary
- clinical picture of acromegaly
- Diagnosis and differential diagnosis of acromegaly
- treatment of acromegaly
- Treatment gigantism
flow forecast anddisabled
have pituitary giants, as well as patients with acromegaly disease is determined by the growth of the intensity of eosinophilic pituitary adenoma and severity of metabolic disorders.Many sick for a long time feel good, have considerable physical strength, and only after many years, the disease goes into the next stage, when there are disorders related to the metabolic effects of growth hormone, is produced in excess, decrease in production of other triple hormones anterior pituitary and compression eosinophilic adenomasurrounding tissues.These symptoms are essentially the same as that in progressive acromegaly.
patients pituitary gigantism working capacity in the presence of these symptoms is reduced to the same extent as in patients with acromegaly.
In the absence of X-ray, ophthalmic and neurological signs of pituitary tumors, deficiency symptoms of the anterior pituitary gland and metabolic disorders, depending on the overproduction of growth hormone, pituitary giants are able to work.