Hormone producing tumors of the ovaries
Endocrinology / / May 06, 2016
hormone producing tumors of the ovary can be divided into a tumor originating from the female gonads, in their clinical manifestations accompanied by feminizing effect, and tumors of the male gonads, which have virilizing effects.
the emergence or other clinical symptoms associated with the generation of tumor cells, an excess amount of estrogen and androgen.
elements of the female gonads are granulosis follicles and tech-fabric.Under physiological conditions, granulosis formed in the maturing follicle;After ovulation, granulosa cells undergo a transformation in the theca lutein, and then comes their atresia.Granulosa cells can exist in the long atresial follicles and follicular cysts.It is believed that estrogen hormones in physiological conditions produced by granulosa follicles.Confirmation that granulosis ability to produce estrogen, is the fact that feminizing her actions if granulezokletochkovyh tumors.However, studies in different years show that not only granulosis follicles, but also the inne
inner sheath of the follicle (theca interna) is formed from the interstitial tissue of the cortical layer.In the process of cyclical changes in the ovary after ovulation occurs its transformation into the theca lutein cells.Ability-tech fabrics to produce estrogens confirmed the clinical manifestations associated with estrogen stimulation during tech-kletochkovyh ovarian tumors.This is also confirmed by the fact that in the Tecom found estrogens;the content of estrogen in the theca kletochkovyh tumors above (4,6-7,3 g / g) than granulezokletochkovyh (0.02-0.3 mg / g).However, in general, tumors rarely consist of only one cell type, we can speak only of the predominance of a particular type of cellular structure in the tumor.Therefore, the presence of estrogen in granulezo- or tech-kletochkovyh tumors can not be the ultimate criterion of the cellular structures of the ovary that produce estrogen.According to the ideas of both types of cells as the granulosa and theca for estrogen products should participate.This assumption is confirmed by the fact that the greatest amount of estrogen - 24.8 ug / g - is found in mixed - granulosa-theca kletochkovyh tumors.
masculinizing tumor from the remnants of the male gonads originate from the brain strands (rete ovarii), of which men come Sertoli cells and ovarian cells of the villi.
ovarian Network is a rudimentary form - a homologue of rete testis is located at the gate of the ovary, and sometimes permeates the medulla.Lacunas and strands that make up the network, lined with epithelium, which are located under the spindle-shaped cells such as ovarian theca tissue.ovary Network is not involved in cyclic transformation.In pathological conditions, it can be a source of growth of the tumor formed from Sertoli cell types that produce large amounts of androgens, which results in significant clinical symptoms of virilization.
Hilyusnye cells are found in the broad ligament of the ovary in the gate, are polygonal, epithelioid structure with the presence of lipids in the form of inclusions.Hilyusnye cells expressed well under the same conditions in which a well-developed network of the ovary.Hyperplasia hilyusnyh cells leads to clinical manifestations of virilization, which gave reason to believe their place of formation of androgens.Hilyusnye cells is considered a homologue leydigovyh cell testicular men.Tumors of hilyusnyh cells have virilizing effect, which confirms the assumption about their ability to produce androgens.However, each of these tissues in pathological conditions can change their function, highlighting how estrogens and androgens.This applies particularly to the tech-fabric, as in some pathological conditions in the syndrome Stein-Leventhal and teka- and theca tumors granulezokletochkovyh-tech fabric is able to secrete androgens.Apparently, in pathologic conditions the same morphological ovary components may have different functional activity.They can function similar to physiological conditions, and paradoxically, producing the opposite sex hormones.
- ovarian hormones.Estrogens
- ovarian anatomy
- ovarian hormones.Androgens
- menstrual cycle Hormonal
- menstrual irregularities
- tests of functional diagnostics of ovarian activity
- Violation monthly rate.Amenorrhea
- Violation of the menstrual cycle with monthly rhythm disorder.Opsomenoreya
- Violation of the menstrual cycle with monthly rhythm disorder.Polimenoreya
- principles of hormone therapy violations
- menstrual Principles of hormonal treatment of dysfunctional uterine bleeding
- Prevention of recurrence of dysfunctional uterine bleeding
- polycystic ovarian degeneration (syndrome Stein - Leventhal)
- Violation bleeding intensity in the menstrual cycle.Dysfunctional uterine bleeding
This is because the path of biosynthesis of estrogens and androgens are very close.Androgens are necessary and closest estrogen precursors.The ovary cells producing estrogens, activity of the enzymes that cause the conversion of androstenedione to estrone and testosterone to estradiol is considerably higher than in the testes cells that produce androgens.Therefore, in the biosynthesis of testicular androgen stops at the stage of that and secreted into the bloodstream and a small part of them is converted into estrogen.In addition, there is another testis testosterone production pathway - through testosterone acetate.The same biosynthetic pathway characteristic, apparently, the cells of the ovaries, which are homologs of the testes.Therefore with increasing number of products are amplified in tumors androgens.But androgen production may increase in granulosa cells and theca, if for some reason reduce the activity of enzymes that cause the conversion of androgens to estrogens, as is the case in some embodiments, Stein-Leventhal syndrome.The cells of the network and ovary ovary gate in which this activity is normally low, it may increase and then the cells, along with the production of androgens, and will produce excessive amounts of estrogens.