Diseases of sex glands and ovaries diseases
Endocrinology / / August 12, 2017
main progestogen in humans - progesterone, which is a C21 -steroids, as besides methyl groups in 10 of 13 carbon atoms, it even has a side chain of 2 carbon atoms at the 17-carbon atom.UT of 20 carbon atoms, progesterone has a keto group, and in the ring "B" -.. Double bond, ie, it is unsaturated diketone.Furthermore progesterone in the ovaries and blood women discovered yet other progestogens different from progesterone in that they have a keto group at 20-position is restored, ie replaced by a hydroxyl radical:.. W-keto-20-a-gidroksipregnen and Z-keto-20-P-gidroksipregnen.
Previously it was thought that progesterone is produced only by the corpus luteum.More recently it is shown that progesterone and W-keto-20-hydroxy-a-H and 20-keto-B-gidroksipregneny contained in a follicle before it breaks, and in the blood flowing from the ovary.According to the data destination progesterone production in the ovaries are granulosa cells.A quantity of progesterone is also synthesized in the adrenal cortex.
daily production of progesterone in the body of women in the follicular phase of the cycle is 100-150 mg, which reflects mainly the production of progesterone by the adrenal cortex and in the luteal phase - 200-500 mg, the bulk of which is produced in the corpus luteum.
in peripheral blood progesterone content is very low (1,3-3,1 mg / 100 ml).This is largely due to the fact that progesterone is fast disappearing from the blood, and much of it goes to fat tissue.
progesterone in the urine is not found, even with the use of modern highly sensitive methods (eg, isotope dilution method in studies).The only urine are progesterone metabolites, of which the core is pregnan-3-a, 20-a-diol.
- ovarian hormones.Estrogens
- ovarian anatomy
- ovarian hormones.Androgens
- Treatment syndrome Cushing's
- androgen-producing tumors of the adrenal cortex
- Biological effects of catecholamines
- diagnosis and treatment of pheochromocytomas
- Diseases of the adrenal medulla
- Treatment of chronic adrenal insufficiency
- Diseases of the thymus (thymus) gland
- relationship thymus gland with endocrine glands
- thymus gland and its physiology
- sTATUS THYMICO-LYMPHATICUS (lymphoidotoxemia)
main biological effects of progesterone is uterine preparationto the perception of a fertilized egg.It is now known a large number of synthetic progestogens, but a number of them, having the properties to cause secretory transformation of the endometrium, unable to maintain a pregnancy after castration castrated animals in the early stages of pregnancy.Progesterone
necessary for the growth of the mammary glands, and in contrast to estrogen, the growth inducing ducts, progesterone promotes the alveoli in the glands.
Progesterone affects metabolic processes, not only in the genitals and mammary glands, but also in many tissues of the body.Thus, it has a weak catabolic effect, leads to the sodium and water retention in many tissues.