The biological effect of mineralocorticoid
Endocrinology / / August 12, 2017
The biological effect of hormones of the adrenal cortex
Aldosterone causes a delay in the body of sodium and chlorine ions and increased excretion of potassium, hydrogen and ammonium ions.This applies both to the kidney excretion of ions and release them later, saliva, feces.The ratio of sodium / potassium in saliva, sweat and feces decreased aldosterone influenced by reducing sodium excretion and (to a lesser extent) by increasing the release of potassium.
When parenteral administration of aldosterone action on its excretion by the kidneys ion begins to appear after 1-2 hours, and fully deployed in 4-5 hours.
In healthy people, in contrast to patients with edema, with the continued administration of aldosterone in a few daysincreased excretion of sodium and substantial delay does not occur in the organism, as well as water retention does not occur, and visible development of edema.This same phenomenon is observed upon administration of corticosteroids having at mineralocorticoid activity than al
Aldosterone stimulates the transport of ions across cell membranes by altering the ratio of extracellular and intracellular sodium and potassium.The ratio of extracellular and intracellular sodium under the influence of aldosterone increases, and the ratio of extracellular and intracellular potassium decreases.
In large doses, aldosterone increases the glomerular filtration rate and reduces the reabsorption of water in the renal tubules.
The experiment aldosterone causes increased blood pressure only with the introduction of many months.In adrenalectomized dogs and in people with Addison's disease, aldosterone administered in doses sufficient to normalize the electrolyte balance, normalizes blood pressure, but does not cause hypertension.However, a person in chronic increase production of aldosterone by the adrenal glands - in Conn's syndrome - hypertension is one of the most constant symptoms.
Aldosterone has a weak glikokortikoidnym action, about three times smaller than cortisol.Because aldosterone blood many times smaller than the content of cortisol, aldosterone glikokortikoidnoe action under physiological conditions is practically hardly manifested.
deoxycorticosterone (DOC) has mineralocorticoid activity, like aldosterone action.MLC 30 times weaker against aldosterone sodium retention and relatively stronger effect on potassium excretion.
- Physiology of the adrenal cortex
- chromophobe pituitary adenoma
- Regulation adrenocortical function
- blood supply and innervation of the adrenal
- Diseases pineal gland
- physiology of the pineal gland and its relationship with the endocrine glands
- Biologicalmineralocorticoid action
- The biological effect of hormones crust nadpochechnikov.Biologicheskoe glucocorticoid action
- Morforfologiya adrenal
- Additional adrenal
- biosynthesis and metabolism of the adrenal cortex hormones
Unlike aldosterone MLC is not an activator ion transport across cell membranes, does not increase the glomerular filtration rate.MLC in a relatively greater degree than aldosterone, has the potential to cause high blood pressure and kidney disease.
proinflammatory action mineralocorticoid studied mainly in relation to the PKD, although there is evidence that such action has and aldosterone.In certain experimental conditions the excess load MLC leads to increased inflammatory response and the development of several pathological conditions (changes in heart and joints reminiscent rheumatic changes in character of malignant nephrosclerosis kidney).Arthralgia were observed with an overdose of PKD patients with Addison's disease.