Causes of kidney stones
Urology / / May 02, 2016
Diagnosis "Urolithiasis" may hide under a variety of pathological conditions of the body: metabolic disorders, hormonal disorders, etc ... Hence the numerous theories of origin and development of urolithiasis, but none of them fully describe this condition.There is an allocation of the trend of the state is not a separate disease but a symptom of certain metabolic or hormonal disorders.
should start with calcium nephrolithiasis, which is more than 80% of all cases of kidney stones.The causes of this disease hypercalcemia, hyperuricosuria, giperoksalaturiya and hypocitraturia.To a lesser extent the cause of primary hyperparathyroidism may be in violation of calcium metabolism (resorptive hypercalciuria).
important pathogenetic mechanism is a violation of the colloidal equilibrium in the urine.The urine is a supersaturated solution, but does not occur in spite of this loss precipitated salts in norm.This property of urine due to the presence of citrate (it has the property of forming soluble complex
great importance in the stone formation are geographic and climatic conditions.For example, kidney stones more common in the Caucasus, in Central Asia, Dalmatia, Bavaria.Apparently, this relationship is based on a specific electrolyte composition of the water and dry climates.
certain role belongs to beriberi.Experimentally found if artificially deprive animals of vitamin A, can cause the development of their stone disease.
Fractures and long stay patients in a horizontal position (which leads to a violation of urodynamics) are often accompanied by stone formation in the kidneys.
Among the factors contributing to the formation of kidney stones, is an infection of the upper urinary tract.Infectious inflammation caused by microorganisms cleaving urea raises the pH of urine, which causes reduction in the amount of protective colloids and enhancement of crystallization (in normal kidneys secrete colloids 1 g per day).Products inflammation (mucus, pus, sloughed epithelium) are involved in the formation of stones.A more complicated question of the role of infection in primary education in the absence of stones in the urinary tract inflammation, even though it is shown that the crystallization of the center are protein structures.
One of the most important factors in the mechanism of stone formation are changes that lead to the violation of urodynamics.For example, malformations of the urinary system, valves and narrowing of the ureter, chronic urinary retention in the bladder, observed in benign prostatic hyperplasia, urethral stricture, organic diseases of the brain and spinal pathways.