Toluene diisocyanate ( desmodur T) , poisoning
Occupational Diseases / / August 12, 2017
Desmodur T - a mixture of two isomers - 2,4 and 2,6-toluene diisocyanate, low-volatile, strong-smelling liquid.It is the main raw material for conventional polyurethanes, and gas-filled, including polyurethane - foam.Toluene diisocyanate used for the production of special adhesives, enamels, lacquers, and also for the production of polyurethane Perlon fiber type.MPC - 0.05 mg / m3.
enters the body through the respiratory system and skin.Is cumulative.Is irritating to the mucous membranes of the eyes and respiratory system.Strong allergens.Cause astmopodobnye state, followed by chronic pulmonary disease, irritate and sensitize the skin to act on the metabolism - lower the redox processes.
Symptoms of acute poisoning
In acute poisoning due to inhalation of vapor or mist symptoms of respiratory irritation of the mucous membranes (tracheitis, bronchitis).Then may develop severe asthma attacks, pneumonia, in severe cases - respiratory and cardiovascular (with a tendency to collapse) failu
In milder subacute poisoning - complaints of headache, dizziness, feeling of tightness in the chest, pain in the eyes, coughing, shortness of breath.Marked decrease in lung capacity.
consequence of severe or repeated cases of poisoning can be autonomic-vascular disorders, in severe cases - vegetative-vascular crises diencephalic nature, as well as bronchitis, asthma, chronic pneumonia, pulmonary fibrosis, emphysema.Perhaps the development of respiratory and heart failure.Quite often there is increased sensitivity to the effects of toluene diisocyanate when returning to work after a break.
similar activities chlorophenyl isocyanate, hlorgeksilizotsianat, hexamethylene diisocyanate.
Symptoms of chronic poisoning
chronic conjunctivitis, sometimes decrease corneal sensitivity, changes in retinal vessels;subatrophic rhinitis, chronic bronchitis.Astmopodobnye characteristic cough with copious sputum, shortness of breath, reduced lung capacity.The phenomena of chronic toxic hepatitis in violation of the protein-lipid and liver function, vegetative-vascular dystonia, sinus arrhythmia, peripheral vascular spasm, myocardial tendency to hypochromic anemia, leukopenia, thrombocytopenia.Perhaps the increase in methemoglobin, Heinz bodies appearance, reticulocytosis.Allergic skin lesions.
for respiratory protection against exposure to complex substances formed during the production process, work in a gas mask;overalls and jackets of cotton material or a coarse cloth.When dealing with liquid products and in the concentration of substances enhancing moments workers must wear overalls made of insulating material based on synthetic rubber.