Atherosclerosis and its causes
Occupational Diseases / / August 12, 2017
great importance the development of atherosclerosis have a lifestyle, diet, and environmental conditions, heredity, and so on. D. At present, this problem is also seen, and from the standpoint of occupational diseases.
In the current view, the basis of the atherosclerotic process are metabolic disorders, primarily cholesterol (hypercholesterolemia, increasing the fraction of B-lipoproteins, and low blood phospholipids, etc.), Leading to the accumulation of cholesterol in the blood and promoting its deposition in the arterial wall.Important role in the development of the disease plays a central nervous system.Violation of the neuro-vascular regulation, increased vascular tone, its sharp fluctuations, the tendency to spastic reactions contribute to a more rapid and massive infiltration of the vessel wall cholesterol.Thus, the prerequisites for the development of atherosclerosis are Vzaimovlijajushchie vascular and metabolic disorders that often occur when exposed to many occupational factors.Have signifi
labor in modern conditions makes high demands on the central nervous system: need processing large amounts of information, fast and accurate response, fast switching, etc. An example is the occupation of the operator control panel, the driver of public transport, the pilot..
Lead Lead is a vascular poison, it increases the tone of vascular smooth muscle Stoic influences occurring in her metabolism.Lead causes the development angiodistonicheskogo syndrome, which can subsequently be transformed into a kind of hypertension on the background created by intoxication.
Violation of lipid metabolism in the direction of hyperlipidemia observed in patients, long-term contact with the lead, especially in patients with chronic lead intoxication.When lead intoxication can occur quite early typical angina with electrocardiographic changes where research on the background of myocardial dystrophy caused by lead.
have people working with lead, there is more early development of atherosclerosis and its more severe.Direct link increase the frequency and severity of atherosclerosis with increasing professional experience.
Carbon disulphide Carbon disulphide
is not only a "nervous", but also vascular poison.Cardiovascular changes occur at the earliest stages of intoxication.It noted the instability of blood pressure indicators with a penchant for hypertensive reactions.
Now it is proved that the inhibitory effects of carbon disulfide on the enzyme system of the liver leads to the accumulation of cholesterol in the body, histamine, and catecholamines.Violation of the biotransformation of cholesterol and thereby observed hypercholesterolemia (on the background of metabolic disorders of catecholamines) lead to the development of atherosclerosis vessels of the heart, brain and so on. D.
The fact of significantly greater mortality from coronary heart disease among workers viscose industry.
Cardiovascular disorders are an essential element of both acute and chronic carbon monoxide poisoning.For the latter characterized by the development angiodistonicheskogo syndrome, the tendency to hypertension with possible further transformation in hypertension, as well as violation of cholesterol metabolism - hypercholesterolemia, reduced bond strength between the protein and cholesterol.
carbon monoxide, transferring part of the hemoglobin in carboxyhemoglobin, causes a disturbance of tissue respiration.Changes are a consequence of hypoxia in the heart muscle and blood vessels.The defeat of the heart muscle occurs on the type of dystrophy.In acute carbon monoxide poisoning may develop focal infarktopodobnyh changes.
physical factors (vibration, UHF, noise)
typical manifestation of vibration exposure are violations of the regulation of vascular tone, often - with the presence of high blood pressure disorders of regional blood flow in vessels of all sizes, mostly peripheral.Patients vibration disease, and to a lesser extent in persons exposed to vibration, changes in cholesterol metabolism observed, similar to those described above under the action of toxic substances.The same violation of cholesterol metabolism detected by electromagnetic fields and radio frequency meter range and a sharp noise.
Thus, a number of chronic exposure to occupational factors may contribute to the development of atherosclerosis by neurovascular disorders with consequent change regulation of hemodynamics, on the one hand, and by interfering with cholesterol metabolism - the other.