Poisoning of acrylic and methacrylic acid
Occupational Diseases / / May 19, 2016
Acrylic acid and its esters (methyl, ethyl and butyl acrylate) - colorless, volatile liquid with a pungent unpleasant odor, polymerized under the influence of oxygen and light when heated.
esters of acrylic acid, particularly methyl, are used in the plastics industry for the manufacture of transparent elastic films possessing high mechanical strength;resins based on acrylic acid are also used in the paint industry.
Methacrylic acid - a colorless liquid with an odor resembling acetic acid.Methyl methacrylate - a colorless liquid with a pungent unpleasant odor.Methacrylic acid and its esters are capable of polymerization.
polymeric methacrylates, especially methyl methacrylic acid (PMMA), are widely used for the manufacture of transparent organic glass films as insulation and construction material in the instrument, in the manufacture of pipes and consumer goods, artificial teeth, dentures and other products for cosmeticsurgery.Furthermore, methacrylic acid esters used in the manufacture of pai
Air environment production facilities contaminated mostly methyl methacrylate vapors and toxic substances from which it is synthesized (acetone cyanohydrin and methanol).The maximum permissible concentration (MPC) for acrylic acid - 5 mg / m3 for methacrylic acid - 10 mg / m3 for the methyl ester of acrylic acid - 20 mg / m3.They enter the body through inhalation and through the intact skin.Acrylic and methacrylic acids and their esters are irritating and narcotic properties, cause injury to internal organs.
In acute poisoning (methyl methacrylate), along with signs of irritation of the eyes and upper respiratory tract, there are nausea, repeated vomiting, headache, ringing in the head, dizziness, thirst, weakness, drowsiness.In the future, - loss of consciousness, transient nature of epileptiform convulsions.Hypotension.Leukocytosis with relative neutrophilia.
In chronic poisoning (methyl methacrylate), a leading position in the clinical picture takes symptoms of nervous system.There are staging of the disease.
For stage I asthenoneurotic intoxication characterized by a syndrome with symptoms of autonomic dysfunction;complaints of general weakness, loss of memory;headache;stabbing pain in my heart;depressed mood;tearfulness;decrease the excitability of the vestibular analyzer.These changes are unstable and smoothed at the termination of the contact with the poison.
For stage II intoxication characterized by the development of autonomic-sensitive polyneuritis with peripheral angiodistonicheskim syndrome and impaired trophism nails.X-ray examination revealed degenerative changes in the bones.
Also observed disorder sight, smell, hearing, vestibular disorders, diencephalic symptoms, chronic conjunctivitis, subatrophic and atrophic changes in the mucous of the upper respiratory tract.Possible effects of gastritis with secretory deficiency and toxic hepatitis.
progression of a transition process in III stage intoxication.Boosts complaints of weakness, apathy, memory loss, etc. is growing neurological symptoms (the development of toxic encephalopathy)..;general tendency to angiodistonicheskim Creasy with hypertension and tachycardia.The ECG - myocardial dystrophic defeat.Sometimes there violation of ovarian-menstrual and reproductive functions.
Methyl and butyl acrylate and methyl methacrylate are less irritating to the skin (dermatitis may develop acute with blistering or dry type necrosis pyoderma et al.).
15 May, 2016
15 May, 2016