Poisoning by organomercury compounds ( diethylmercury , ethyl Merkur phosphate etilmerkurhlorid , Granosan , merkuran )
Occupational Diseases / / May 16, 2016
Organic mercury compounds in the form of powders, and solutions are used as insectofungicides as wood preservatives.Contact with them as possible into their shops synthesis.Basic connections: diethylmercury - a colorless liquid with a faint, unpleasant odor.Etilmerkurfosfat - white crystalline solid.Etilmerkurhlorid - white shiny crystals.Granosan - white or light gray powder with a specific smell.Merkuran - fine powder of white or grayish color with a strong odor.MPC for all of the above substances (mercury content) - 0.005 mg / m3.
enters the body through the respiratory system, gastrointestinal tract and skin.Long circulate in the blood, are found in all tissues;through the placenta into the fetus receives.Slow excretion, mostly in the urine and feces.Perhaps finding mercury in the urine within 2-3 years after the cessation of contact.It accumulates in the brain, liver, kidney, colon, adrenal glands.It is easy to break the blood-brain barrier, directly getting into the cerebrospinal fluid.Hence thei
These substances cause diencephalic lesions, mental disorders, the functions of the endocrine glands, especially the thyroid;have allergenic, embryotoxic and mutagenic.There may be both productive and household poisoning.
Depending on the way the proceeds is usually a certain sequence of symptoms.Inhalation poisoning first signs is dominated by damage to the nervous system when orally - dyspeptic symptoms.Characterized by a long latency period (up to several weeks).
most important are granozanom intoxication - acute, subacute and chronic.
Acute granozanom mild : slight irritation of the upper respiratory tract, metallic taste in the mouth, salivation, gingivitis, nausea, vomiting, diarrhea - in the background asthenovegetative syndrome.The phenomena are reversible within a few weeks.
With moderate intoxication gradually develops a picture of acute encephalopathy with a primary lesion of the cerebellum, the brain stem, nuclei of cranial nerves (auditory and visual) with neuro-psychiatric disorders.Arterial hypotension, sometimes hypertension.There are a diencephalic syndrome, toxic hepatitis, and nephrosis.
Severe forms are characterized vestibular-cerebellar, tabloid lesions, paralysis, psychosis, impaired hearing and vision, including blindness, impaired function of the midbrain (sharp emaciation, weakness, diabetes insipidus).Possible hypo- or hyperthyroidism.In blood observed moderate hypochromic anemia, increased erythrocyte sedimentation rate, leukocytosis with neutrophilic shift to the left, relative lymphocytosis, monocytosis, decreased serum protein;in urine - albuminuria, hematuria, urobilinuria, the presence of mercury (0.03-0.05 mg / L and more).
subacute and chronic poisoning
Trembling extremities, headaches, sleep disturbance - persistent insomnia, daytime sleepiness, anxiety, memory loss, weakness, weight loss, weakness.Sudden dizziness, fainting.Mental disorders - apathy, anxiety, hallucinations.Diencephalic syndrome: diabetes insipidus (a thirst, polyuria to 6 liters per day), irrational fear, choking, heart attacks with fever, disturbances in thermoregulation, sweating.Entsefalopolinevrit.The defeat of the myocardium and the conduction system of the heart.Severe vascular disorders.Ulcerative stomatitis, diarrhea.Hepatitis.Nephropathy.Violations of the functions of the pituitary-adrenal system, thyroid.Anemia, a shift to the left and degenerative changes of neutrophils, mono- and lymphocytosis.Lowering blood sugar, cholesterol.In urine, long time (2-3 years) detected mercury (over 0.03 mg / l).Allergic diseases of the skin (rashes, dermatitis).
changes caused by acute and chronic poisoning by organomercury compounds are very stable.
disability If you suspect pas intoxication or detecting elevated amounts of mercury in the urine must be suspension from contact with mercury and other toxic substances.Taking into account the stability of intoxication, it recommended a complete cessation of all kinds of contact with mercury compounds, even in cases of "light" intoxication;absolutely contraindicated work with them after acute poisoning moderate to severe and chronic intoxication.
Sealing of the entire apparatus.Elimination of manual operations.Personal protection measures (respirators, masks, goggles, coveralls, rubber boots).
18 Apr, 2016
18 Apr, 2016