Occupational Diseases / / May 10, 2016
Trichloroethylene - colorless, nonflammable liquid with odor reminiscent of chloroform.In case of contact with an open flame, when heated to 410 degrees, and in the sunlight forms phosgene.Used as a solvent resins, pitches, rubber, for cleaning metal parts, textiles and other MPC -. 10 mg / m3.It enters the body through the respiratory system.Perhaps percutaneous absorption.The ingestion of 50-100 ml - severe poisoning death.
About 20% of light is released unchanged.The main part and the metabolites are excreted in urine.It has a narcotic and slightly irritating.It affects the central and peripheral nervous system, and a lesser degree - the liver and kidneys;It causes skin changes.
case of brief inhalation of concentrations below narcotic observed irritation of eyes and upper respiratory tract, vasomotor and dyspepsia, dizziness, headaches, intoxication, nausea, vomiting.After leaving the polluted atmosphere all phenomena take place relatively quickly.There may be mental disorders.I
high concentrations quickly without prodromal period there comes a state of anesthesia, which can result in a deep coma with signs of heart disease (premature beats, ventricular fibrillation), and liver.
sometimes develop pneumonia and toxic pulmonary edema.Typically the subsequent defeat of the trigeminal nerve, at least - other cranial nerves.Possible nevroparalitichesky keratitis, blurred vision, loss of teeth.
Chronic intoxication mild to moderate observed asthenia, feeling drunk, sleep disturbances, headaches, dizziness, fatigue, disturbances of smell.Pain in the limbs, in the heart, loss of appetite, impotence.Vegetative-vascular changes with a tendency to bradycardia and hypotension, arrythmia, low-grade fever.Later joined the scattered signs of central nervous system can be observed and vegetative-sensitive polyneuritis.
In severe cases - a picture of toxic encephalopathy with cranial nerve (hypoglossal, trigeminal, visual), polyneuritis.Later joined by mental disorders (irritability, mood instability, state of arousal).Known hypersensitivity to the habits of persons exposed to trichlorethylene (expansion of peripheral vascular, drop pressure, tachycardia, dyspnea).Alcohol test may be recommended to determine the impact of trichlorethylene.Frequent violations of the secretory function of the stomach, irritation of eyes and upper respiratory tract, chronic bronchitis with symptoms of bronchospasm.Sometimes there is a kind of addiction - addiction to smell trichlorethylene, which increases the risk of chronic poisoning.In the blood - hypochromic anemia, mild leukopenia, relative lymphocytosis.
in women - menstrual dysfunction, adverse pregnancy and birth.
After contact with trichlorethylene marked staining of the skin and nails, ulcers terminal phalanges, dermatitis and eczema, mainly on the hands, sometimes common forms.
There are cases when the action against chronic trichlorethylene at short-term increase of its concentration at an unusual physical exertion, or for no apparent reason there are serious or even fatal poisoning may result in fibrillation of the heart and stop it.After termination of trichlorethylene may persist for a long time a number of symptoms of chronic exposure to it.
Determination of trichlorethylene metabolites in the urine level has diagnostic value.In healthy people working with trichlorethylene, the total amount excreted in the urine and trichlorethylene trichloroacetic acid is not more than 70-75 mg / l.If signs of intoxication metabolites content increases, and at the expressed symptoms - up to 200 mg / l.Therefore recommend temporary transfer to a job out of contact with trichlorethylene detection in the urine of working its metabolites in an amount of about 100 mg / l.