Carcinogenic effects of viruses
Oncology / / May 10, 2016
plurality of known viruses that in various animal species (mammals and birds) cause neoplastic diseases.According to many reports, the viruses can cause cancer in humans.Depending on the nucleic acid content in the genome is divided into carcinogenic DNA viruses and RNA viruses.The group of DNA viruses are polyoma, papilloma, adenoviruses and herpes viruses.Carcinogenic viruses are RNA viruses onkorna generalizing the name and under the ultrastructure are divided into types A, B and C. Type A particles are immature virions;among type B viruses is Bittner factor causing breast carcinoma.The viruses of type B can cause different types of leukemias and sarcomas.
For tumors that contain a virus, characterized by that on the surface of tumor cells can be detected tumor agents induced by the virus.Make a conclusion about the viral origin of the tumor as possible and on the basis of a tumor specific antigen, as is often the case that most of the tumor virus is no longer detectable.
disease of chickens - Mare
After confirming the viral origin of breast cancer in mice, leukemia chick and rabbit papillomavirus was detected several tumors of viral origin, which were caused by animals.The best known among them are lymphoid and myeloid leukemia mice.Different types of tumors in mice could induce leukemia viruses, such as the parotid gland tumor, breast cancer and cancer of the adrenal glands.This type of virus called a virus polyoma.It belongs to the group of papovaviruses viral DNA.The monkey kidney culture found SV40 virus that hamster in the site of implantation induced sarcoma.SV40 virus capable of transforming a cultured human tumor cells.
on human tumors at the forefront of research is of viral origin lymphomas and primarily Burkitt's lymphoma.Burkitt in 1958 described a new disease, observed by him in East Africa in children, which was accompanied by swelling of the jaw, face and neck.Tumor affects the orbital zone and metastasized to internal organs.It was found that this disease is a special form of lymphoma.It is believed that the tumor causes the virus Epstein - Barr virus (EBV), which belongs to the herpes virus, which in a number of Asian countries is the probable cause of nasopharyngeal carcinoma.Pathogenic role of the virus and suggests infectious mononucleosis.Antigen herpes simplex virus 2 (HSV2) was found in cancerous human cervical tumor.