Helminthiases / / August 12, 2017
Opisthorchosis (Lat.), Opisthorchiasis (Eng.), Opisthorchiase (fr.), Opisthorchosis (App.)
Distinguish opistorhoz (Vinogradova disease) in Western Siberia and the Far East and Europe.The first kind opisthorchiasis common in the population pool of Ob and Irtysh (Western Siberia, Kazakhstan), Kama and Volga, Dnieper, Don and Donets, Northern Dvina, Neman.Far opistorhoz distributed mainly in the Thai population.
Etiology and epidemiology
of Opisthorchosis are two species of trematodes - Opisthorchis felineus and O. viverrini.The first - the causative agent Vinogradov, second - Far East opisthorchiasis.Opisthorchis felineus, often referred to as a fluke or a Siberian cat has a flat body length of 4-13 mm and a width of 1-3.5 mm.The eggs are pale yellow, with a lid, and a thickening of the shell at the poles, the size of 0,011- 0,019 X 0,023-0,034 mm.
in puberty stage of a parasite in the bile and pancreatic ducts and the gallbladder human, cat, dog, fox, fox and other mammals.Intermediate host opist
O. viverrini similar to O. felineus.Its length 5,4-10,2 mm, width - 0.8-1.9 mm.At the stage of puberty it is parasitic in humans, cats, dogs, carnivorous animal civet.Intermediate hosts - molluscs Bithynia funiculata and other additional owners -. Carp fish.
causative agent Vinogradov
excreted in the faeces of patients opisthorchiasis human and animal eggs opisthorchiasis in contact with them in the water ingested by mollusks.The shellfish is the development and proliferation of larval generations of worms, in 2 months.ending with the release of the water tailed larvae - cercariae.Cercariae actively penetrate the carp fish and accumulate in their subcutaneous tissue and muscles.Infection opisthorchiasis humans and mammals occurs by eating raw, slightly salted or insufficiently cooked fish.
- Symptoms opisthorchiasis
- treatment, prevention and prognosis of opistorhoze
Pathological anatomyand pathogenesis
in the early phase of opisthorchiasis occur in the liver and degenerative necrobiotic processes infiltrates.In the late phase of helminthiasis at autopsies of people who died from various diseases, often found adhesions of the liver and gallbladder to the stomach and intestines.Liver intensive opisthorchosis increased and sealed on its surface many small elevations.Through Glisson capsule in the form of whitish cords and bubbles appear through advanced, with a thickened wall of the bile ducts.Particularly dramatic changes observed at the edge of the body where there is a large number of cysts of the bile ducts in size from a millet seed to a pea.Sometimes seen deep scar retractions.
The adenomatous proliferation of the bile duct epithelium, thickening of the walls.Around the affected ducts proliferation of connective tissue (periangiocholitis), which sometimes surrounds the lobules of the liver and even penetrates between the beams of liver cells.With a large number opistorhisov gradually develops holangitichesky zooparazitarny cirrhosis.Extrahepatic bile ducts dilated, with a thickened wall, often convoluted.The gall bladder is often enlarged and tight, his bloodshot wall, on the mucous membrane proliferation and desquamation of the epithelium, epithelial growths are frequent in the form of warts.
The pancreas epithelial proliferation, wall thickening and expansion of the lumen of the ducts in their sclerotic changes circle.
in the pathogenesis opisthorchiasis is dominated by poisoning of the body of the patient products parasite metabolism, mechanical impact opistorhisov, neuro-reflex influences, secondary bacterial infection.Thus creating the prerequisites for the emergence of primary liver cancer and pancreatic cancer.